Phosphatoquinones A and B, novel tyrosine phosphatase inhibitors produced by Streptomyces sp.

نویسندگان

  • T Kagamizono
  • T Hamaguchi
  • T Ando
  • K Sugawara
  • T Adachi
  • H Osada
چکیده

Phosphatoquinones A and B were isolated from the cultured broth of Streptomyces sp. TA-0363 and their structures were elucidated by spectroscopic analyses. Phosphatoquinones A and B inhibited the protein tyrosine phosphatase activity prepared from human Ball-1 cells with IC50 of 28 microM and 2.9 microM, respectively.

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عنوان ژورنال:
  • The Journal of antibiotics

دوره 52 2  شماره 

صفحات  -

تاریخ انتشار 1999